Nomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: A multicentric prospective study with external validation
نویسندگان
چکیده
منابع مشابه
Prospective assessment of imaging after preoperative chemoradiotherapy for rectal cancer.
BACKGROUND The aim of the study was to assess the accuracy of imaging techniques in predicting pathologic tumor (ypT), node (ypN) stages and the circumferential resection margin (ypCRM) status of rectal cancers after preoperative chemoradiotherapy (CRT). METHODS Using pelvic computed tomography (CT), magnetic resonance imaging (MRI), and endorectal ultrasound (ERUS), 90 consecutive patients w...
متن کاملA nomogram predicting pathological complete response to neoadjuvant chemoradiotherapy for locally advanced rectal cancer: implications for organ preservation strategies
PURPOSE To determine predictors of pathological complete response (pCR) in locally advanced rectal cancer patients treated with neoadjuvant chemoradiotherapy (nCRT), and develop a predictive nomogram. METHODS A total of 522 locally advanced rectal cancer patients undergoing nCRT and curative resection between 2008 and 2014 were included. Uni- and multivariate analysis was performed to identif...
متن کاملMagnetic resonance imaging in restaging rectal cancer after neoadjuvant chemoradiotherapy.
PURPOSE To evaluate the accuracy of magnetic resonance imaging (MRI) for restaging locally advanced nonmucinous rectal cancer after neoadjuvant chemoradiotherapy (CRT). METHODS A total of 94 consecutive patients with histologically proven locally advanced middle or low located nonmucinous rectal adenocarcinoma, who were treated with preoperative CRT, followed by radical surgery 6-8 weeks late...
متن کاملPositron emission tomography for predicting pathologic response after neoadjuvant chemoradiotherapy for locally advanced rectal cancer.
PURPOSE To investigate whether before and after chemoradiotherapy (CRT) positron emission tomography (PET) predict for pathologic response after preoperative CRT in patients with locally advanced rectal adenocarcinoma. METHODS Thirty-five patients who underwent pre-CRT and post-CRT PET scans before surgery were included. All patients were staged with endoscopic ultrasound or high resolution C...
متن کاملChemoradiotherapy response in recurrent rectal cancer
The efficacy of response to preoperative chemoradiotherapy (CRT) in recurrent versus primary rectal cancer has not been investigated. We compared radiological downsizing between primary and recurrent rectal cancers following CRT and determined the optimal size reduction threshold for response validated by survival outcomes. The proportional change in tumor length for primary and recurrent recta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Radiotherapy and Oncology
سال: 2014
ISSN: 0167-8140
DOI: 10.1016/j.radonc.2014.11.002